Cytotoxic Activity of Green Seaweed Halimeda tuna Methanolic Extract Against Lung Cancer Cells

Authors

  • Amir Husni Department of Fisheries, Universitas Gadjah Mada, Yogyakarta-55281 (Indonesia) Author
  • Mohamad Gazali Department of Marine Science, Teuku Umar University, West Aceh-23681 (Indonesia); Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu-21030 (Malaysia) Author
  • Nurjanah Nurjanah Department of Aquatic Product Technology, IPB University, Bogor-16680 (Indonesia) Author
  • Rina Syafitri Department of Agribusiness, Teuku Umar University, West Aceh-23681 (Indonesia) Author
  • Abdul Matin Department of Food Processing and Engineering, Chattogram Veterinary and Animal Sciences University, Chattogram-4225 (Bangladesh); Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu-21030 (Malaysia) Author
  • Zuriat Zuriat Department of Fisheries, Teuku Umar University, West Aceh-23681 (Indonesia) Author

DOI:

https://doi.org/10.47352/jmans.2774-3047.61

Keywords:

steroid

Abstract

Lung cancer is a malignant tumor that attacks the lungs generated by carcinogenic free radicals such as cigarette smoke. Seaweed contains bioactive compounds that have the potential to reduce cancer-causing free radicals. This study aimed to determine the phytochemical content and cytotoxic activity of Halimeda tuna seaweed extract against lung cancer cells (A549). The H. tuna sample was macerated using methanol for 24 h. Cytotoxic test of H. tuna crude extract used the MTT test against A549. The crude extract was phytochemically tested and analyzed using gas chromatography–mass spectrometry (GC-MS). The results showed that the H. tuna crude extract had cytotoxic activity against A549 with an IC50 value of 2771 µg/mL. The phytochemical test showed that H. tuna crude extract contained flavonoids and steroids. showed the presence of fatty acid compounds including palmitic acid, oleic acid, myristic acid, palmitoleic acid and stearic acid. Based on the results can be concluded that H. tuna extract had cytotoxic activity against A549 with low cytotoxicity to be used as a chemo-preventive agent.

Downloads

Published

2024-01-31

Issue

Vol. 4 No. 1 (2024): Journal of Multidisciplinary Applied Natural Science

Section

Articles

License

Copyright (c) 2024 Amir Husni, Mohamad Gazali, Nurjanah Nurjanah, Rina Syafitri, Abdul Matin, Zuriat Zuriat (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:
  1. Authors retain copyright and acknowledge that the Journal of Multidisciplinary Applied Natural Science is the first publisher, licensed under a Creative Commons Attribution 4.0 International License.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges and earlier and greater citation of published work.